Pharmacokinetic Aspects of Anxiolytic Drug Therapy

Pharmacokinetic aspects of retinal drug delivery

Drug delivery to the posterior eye segment is an important challenge in ophthalmology, because many diseases affect the retina and choroid leading to impaired vision or blindness. Currently, intravitreal injections are the method of choice to administer drugs to the retina, but this approach is applicable only in selected cases (e.g. anti-VEGF antibodies and soluble receptors). There are two ba...

Laboratory aspects of intermittent drug therapy.

The drug-parasite relationships for isoniazid and rifampicin have been investigated, using cultures of M. tuberculosis and infected guinea-pigs. It is remarkable that there appear to be two entirely different mechanisms involved in intermittent chemotherapy with isoniazid and rifampicin. With isoniazid, any escape from the influence of the drug leads to diminished efficacy. On the other hand, w...

nanotechnology-based drug delivery systems: a general overview of the pharmacokinetic aspects

Pharmacokinetic Drug

Pharmacokinetic Changes in Liver Failure and Impact on Drug Therapy.

P harmacokinetics is a term that describes the time course and fate of a drug in the body. The term encompasses drug absorption, distribution, metabolism, and elimination and is often referred to as drug disposition.1 Absorption is defined as the process by which a drug enters the systemic circulation, distribution is the movement of the drug between body compartments, and metabolism encompasse...